The Wachowski siblings share writing and directing duties on the film with Tom Tykwer, director of 'Run Lola Run' and the 2009 Clive Owen thriller 'The International.'
'Cloud Atlas' is a complex novel made up of six separate stories that take place across time and throughout the world, from the remote South Pacific in the 19th century to a post-apocalyptic future.
Filming begins this summer in Germany with an eye toward a May 4, 2012, release.
The Wachowski siblings are best known as the writers and directors of the groundbreaking 'Matrix' trilogy. Their last film, 2008's 'Speed Racer,' starring Emile Hirsch and Christina Ricci, failed to connect with audiences, grossing only $44 million on a $120 million production budget.