Frankly, there are a lot of Vampire movies out there that are already comedies, like Vampire in Brooklyn or any of the Twilight movies. Given their filmography, my expectations for this one are suitably low. I may even be willing to catch it in the theaters, provided I don't actually have to pay money to get in.
It's a fair bet that whatever Misters Friedberg and Seltzer do it will probably make its money back and then some (ah, the business of show and the lack of sophistication of American tastes). But hey, if they want to mock the Twilight franchise, they may do so with my blessing.