His role as Lawrence Talbot in The Wolfman represents the curse of type-casting at its worst. It's clear now that Del Toro will only be considered for roles that call for a half-puppy/half-man hybrid. I'm expecting him to tackle the role of Snoopy in a live-action version of You're a Good Man, Charlie Brown very soon. (I'm also kidding.)
You don't think The Wolfman is even remotely similar to Big Top Pee-Wee because one is a gothic horror and one is a silly comedy? Consider this -- Pee-Wee Herman makes out with both Valeria Golino (whatever happened to her?) and Penelope Ann Miller in the film. Pee-Wee's tongue in your mouth? That's scarier than anything that happens in The Wolfman.