2010 has brought us quite a few casting changes to upcoming comic properties. First Thor got a last minute change-up, and now Red has swapped Johns. According to The Hollywood Reporter, John Malkovich has replaced John C. Reilly in Summit's adaptation of the Warren Ellis miniseries. Reilly left in late December for unknown reasons, but as that dreaded phrase "creative differences" hasn't been cited, we'll take it to be a schedule conflict or something friendly like that.

Malkovich will play a retired CIA Agent, a one time contemporary of Bruce Willis' ex-assassin, only he has gone completely paranoid. He believes everyone is out to kill him, which is undoubtedly confirmed when a bunch of younger, more able agents show up to kill Willis. THR notes that the role will allow him to stretch those considerable, but rarely seen comedic talents. It should be pretty amusing. It'll be like if his character in In the Line of Fire was harmless instead of intent on using his gifts of weapon making for evil.

Malkovich joins an already killer (no pun intended) ensemble of Morgan Freeman, Helen Mirren, Mary-Louise Parker, Julian McMahon, Richard Dreyfuss, Ernest Borgnine and Brian Cox. That's like Coen Bros level of cool, isn't it? Filming begins this week in Toronto, and the film is scheduled to be released November 19, 2010. Think it could be an awards contender with that date?