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Vincent D'Onofrio played Orson Welles in Tim Burton's 'Ed Wood,' and now he's preparing to portray another one-of-a-kind Hollywood mogul.

Screen Daily reports that D'Onofrio will take on the role of Miramax Films co-founder Harvey Weinstein in 'Down and Dirty,' an adaptation of Peter Biskind's nonfiction bestseller, 'Down and Dirty Pictures: Miramax, Sundance, and the Rise of Independent Film.' The film will be produced by Yamani Pictures, which also has director Bill Condon's Richard Pryor biopic 'Is It Something I Said' (starring Eddie Murphy) on its upcoming production slate. Vincent D'Onofrio played Orson Welles in Tim Burton's 'Ed Wood,' and now he's preparing to portray another one-of-a-kind Hollywood mogul.

Screen Daily reports that D'Onofrio will take on the role of Miramax Films co-founder Harvey Weinstein in 'Down and Dirty,' an adaptation of Peter Biskind's nonfiction bestseller, 'Down and Dirty Pictures: Miramax, Sundance, and the Rise of Independent Film.' The film will be produced by Yamani Pictures, which also has director Bill Condon's Richard Pryor biopic 'Is It Something I Said' (starring Eddie Murphy) on its upcoming production slate.

Biskind's 'Down and Dirty Pictures' is another of the author's no-holds-barred examinations of Hollywood, concentrating on the independent film movement of the '90s, of which Miramax was a major player. Biskind is also the author of 'Easy Riders, Raging Bulls,' which chronicled the entertainment industry from the late '60s through the '70s.

We think Vincent D'Onofrio's intensity, eccentricity and larger-than-life physicality make him the perfect choice to play Harvey Weinstein. What remains to be seen is if the film adaptation of 'Down and Dirty' is able (or willing) to capture the book's alternately oddly affectionate and unapologetically scathing portrait of the Miramax man.