Meredith over at io9 has taken the time to look over this year's Sundance selections to find the sci-fi for us, and surprisingly, there are a few to choose from.
Vincenzo Natali, who directed Cube, episodes of Earth: Final Conflict, and, interestingly enough, a segment in Paris, je t'aime, brings Splice to Sundance. Splice is about a new animal species ambitious young scientists engineer, making them celebrity scientists. Apparently they introduce human DNA into their experiment. The cast includes Adrien Brody, Sarah Polley, Delphine Chaneac, David Hewlett. Natali wrote the screenplay with Antoinette Terry Bryant, and Doug Taylor.
The Violent Kind is written and directed by The Butcher Brothers (Mitchell Altieri and Phil Flores). Here, a group of rowdies partying at a secluded farmhouse are tormented by a mysterious force. The cast includes a number of lesser known actors, including some scream queens.
Lastly, All My Friends Are Funeral Singers by first time director Tim Rutili stars the sublime Angela Bettis (May) as a fortune teller in a house overpopulated with ghosts who suddenly realize they are trapped and begin to rebel.
I would also add Life 2.0 directed by Jason Spingarn-Koff, who has worked on a number of Nova programs, with this doc about Second Life.