CATEGORIES Movies, Hot Topic
Ever since Katharine Hepburn hooked up with Spencer Tracy, Hollywood producers have lived by one commandment when casting: When chemistry works, don't change it.

The latest example is the upcoming comedy 'TMI,' which re-teams 'Just Friends' and 'Waiting' co-stars Ryan Reynolds and Anna Faris. In movies, of course, familiarity doesn't breed contempt. It breeds sequels.

So here are few on-screen couples who, for better or for worse, we'd like to see hook up at least once more-and what it might look like. Ever since Katharine Hepburn hooked up with Spencer Tracy, Hollywood producers have lived by one commandment when casting: When chemistry works, don't change it.

The latest example is the upcoming comedy 'TMI,' which re-teams 'Just Friends' and 'Waiting' co-stars Ryan Reynolds and Anna Faris. In movies, of course, familiarity doesn't breed contempt. It breeds sequels.

So here are few on-screen couples who, for better or for worse, we'd like to see hook up at least once more-and what it might look like:

Vince Vaughn & Jennifer Aniston
Previous hookup: 'The Break-Up' (2006)
Too soon? Nah! After being fired from her drab waitress job for not wearing enough 'flair,' Aniston takes her unruly yellow Labrador to a hard-fought dodgeball tournament, where Vaughn is the slovenly but goodhearted star. When a stray throw strikes her in the head, the dog devours the ball. A furious Vaughn threatens legal action, but instead falls head over heels for her. C'mon, it's Jennifer Aniston!

Steve Carell & Catherine Keener
Previous hookup: 'The 40 Year Old Virgin' (2005)
A beautiful but beleaguered single mom panics when her son runs away from home. At first, she searches a faraway island full of strange furry creatures. Failing to find him, she tracks him down in Scranton, Pennsylvania, where he's taken a job at a small-time paper distributor. She falls for the eccentric branch manager, unaware that he's in fact a secret agent. Head in hands, she moans, "What am I doing? I could be working for Spike Jonze!"

Brad Pitt & Angelina Jolie
Previous hookup: 'Mr. & Mrs. Smith' (2005)
Gosh, whatever happened to these two? You'd think there would be some news about them in a magazine or something ... Anyway, Pitt will play an American officer in World War II who heads up a crack squad of beautiful tattooed women, who plan on winning the war by adopting every single child in Europe.



Adam Sandler & Drew Barrymore
Previous hookups: '50 First Dates' (2004), 'The Wedding Singer' (1998)
Sandler and Barrymore both play against type in this surprisingly tense psychological thriller. Barrymore plays a woman in the throes of a breakdown, as she awakens for 50 straight days from a dream about a mullet-wearing waterboy singing "Love Stinks" who's carrying an all-powerful remote control. With every click, he sends her back into a parallel world in which she writes hit lyrics with a much, much handsomer man.

Tom Hanks & Meg Ryan
Previous hookups: 'Joe Versus the Volcano' (1990), 'Sleepless in Seattle' (1993), 'You've Got Mail' (1998)
A dissatisfied New York woman gathers at a resort with her girlfriends, but meets a haunted WWII veteran, whose Tourette syndrome has left him screaming "Wilson" at inopportune times. However, his symptoms gradually disappear, thanks to the love of a good woman -- and a whopping dose of snappy Nora Ephron banter.

Ben Stiller & Cameron Diaz
Previous hookup: 'There's Something About Mary' (1998)
Several years after winning his Oscar for 'Tropic Blunder,' action hero Tugg Speedman has saved enough cash to start a super-secret detective agency. His most valuable undercover agents are three beautiful girls ... who can absolutely kick his butt.



John Cusack & Ione Skye
Previous hookup: 'Say Anything...' (1988)
Lately, Cusack has been seen trying to avoid the end of the world in '2012,' while Skye hasn't seen a hit in ages. One thing's for sure: we do NOT want a sequel to this teen-angst classic. For starters, instead of holding up a boom box playing 'In Your Eyes,' he'd simply send her an MP3 file, which isn't very cinematic. No, we want to see her come back as another one of Rob Gordon's all-time great breakups from 'High Fidelity,' with the two falling in love over some great Solomon Burke records on vinyl.

Robert Redford & Barbra Streisand
Previous hookup: 'The Way We Were' (1973)
Now, this needs a sequel. But after all these years, it'd probably be called 'The Way We Were, as Best As We Can Remember.' By now, though, Hubbell Gardner has turned to the right, and is working as a Fox News anchor. Katie Morosky, meanwhile, has been arrested for staging a sitdown protest in the Fox lobby. Digging through her purse, she finds his yellowed business card, and calls him. After a long silence, he rolls his eyes and barks, "Call my agent." D'oh!

Dustin Hoffman & Katharine Ross
Previous hookup: 'The Graduate' (1967)
In 'The Player,' Buck Henry nailed 'The Graduate, Part 2' ("Mrs. Robinson has had a stroke ... but it's funny!"). So that's out. Rather, we'd like Hoffman and Ross to team up for a rom-com about an autistic man who falls in love with a beautiful divorcee -- who turns out to be a robot from Stepford! Of course, he doesn't mind: '2,785 electrodes. Yeah, definitely, 2,785." But it's funny.