Sony's thriller The Tourist just keeps sending its talent packing. Originally set to be a vehicle for Tom Cruise and Charlize Theron, it shifted gears last month and was re-cast with Angelina Jolie and Sam Worthington. But once again, The Tourist finds itself without travel arrangements for a male lead as Variety reports that Worthington is out due to "creative disagreements" and Johnny Depp is in.

Depp is still in talks to play the hapless American tourist, and with the way this film is going, one can't assume it's finalized. But if it is, it might just be the casting coup of 2010. A Depp-Jolie pair-up has been something dreamed about by a lot of producers and studios over the years. Once upon a time, rumor even had them attached to play Cathy and Heathcliff in Wuthering Heights. People want to see them having onscreen sex. It'd be the hottest thing since ... well, Brad Pitt and Jolie having sex onscreen. (And off. Hey, I'm just being honest. There was a reason everyone wanted to see their offspring.)

The Tourist is also on the hunt for a director. Florian Henckel von Donnersmarck was circling the project, but departed alongside Worthington over those whispery creative differences. Reportedly, a lot of directors are interested, including Alfonso Cuaron. While shake-ups can be be a sign of a bad film, I'd like to think that a thriller that winds up with Jolie, Depp, and Cuaron came together exactly as it was meant to.