Case in point: Val Kimer vs. William Atherton in Real Genius. Bill Murray vs. William Atherton in Ghostbusters. Bruce Willis (and Bonnie Bedelia) vs. William Atherton in Die Hard and Die Hard 2. Pauly Shore vs. William Atherton in Bio-Dome. Certainly no one-trick pony (you also know this actor from The Sugarland Express, The Day of the Locust, and The Last Samurai), but the man's just great at playing a snooty villainous bastard. For those who require some evidence, I refer you to the post-jump territory.
More on Atherton: To find out which giant TV show he'll be guest starring on during its final season, head over to SciFi Squad.
A little salty language in this classic Ghostbusters clip:
A simple-but-amusing capper from Die Hard:
And here's a lengthier segment from Real Genius that truly showcases Atherton's mustache-twirly awesomeness: