Reese WitherspoonDrugs could make a good girl go bad. Reese Witherspoon, who rose to stardom as a good girl in bubbly comedies Legally Blonde and Sweet Home Alabama before winning an Oscar for the dramatic Walk the Line, will star in and produce Pharm Girl for Universal Pictures. Here's the "bad" part: Glenn Ficarra and John Requa, responsible for I Love You Philip Morris but best known for writing the acerbic Bad Santa, "are writing the screenplay and in talks to direct," according to The Hollywood Reporter.

It's hard to believe it's been 18 years since Reese debuted as a spunky young teen in Robert Mulligan's evocative The Man in the Moon. In the decade before Legally Blonde, she gave a scorching performance as an incredibly foul-mouthed, rebellious teen in Matthew Bright's super-dark Freeway (which had a biting comic edge), and eventually won wide acclaim in Alexander Payne's superb Election. It would be refreshing to see sweet Reese go dark in her comedy again, after all the lighter humor that's become her trademark.

Reese has a host of other potential projects boiling right now: Alexander Payne's little people flick Downsizing, clone comedy Used Guys, and James L. Brooks' softball romantic comedy. I haven't been too excited by her recent films, whether comic (Just Like Heaven) or dramatic (Rendition), but it was good to hear her distinctive Southern twang in Monsters vs. Aliens, and I'd like to see the Bad Santa boys cook up a twisted, irreverent satire about the "dark underbelly" of the pharmaceutical industry. Would you go see Reese as a bad "pharm girl"?