Black says Kirsten Dunst is returning as Mary Jane, which may quash all that undecided talk that has plagued the film since it was first announced. However, there are no plans to unite Peter and Mary Jane in holy matrimony. All rumors of Morbius being the villain are false, but it will be someone from the Spidey comics, and Black drops a very slight hint as to who it could be: "We're just coming up with who the villain's going to be now. We'll be shooting in New York again. Trust me, people will appreciate who we pick, because it'll be a big part of New York."
The villain that hint really points to is Kingpin, but he was in Daredevil which suggests Fox has the rights to that particular villain. (Are there crossover claims? I honestly have no idea.) There are a lot of similar mobsters to pick from, but would they resist the temptation for a supervillain and go all real-world? As for other NY based villains, could it be Wraith? He was a NYPD patrolman, and has a tragic origin story that would be pretty ideal. Two weaker suggestions would be Jackal, who was an Empire State University professor, but as they didn't kill Gwen Stacy, I don't know how they would work him in. I think Hydro-Man lives in the Hudson, but that skirts too close to Sandman. Argh, I'm no good at this guessing game. I'll hand it over to you Spidey fans and go enjoy the weekend.