The plot follows a naive waitress, Alice, who is shot in the head with a nail. The injury causes her behavior to be erratic and outrageous (the IMDb says it causes her to become a sexually adventurous bombshell), and she heads to Washington to campaign on behalf of better health care for the freakishly injured. She ends up falling for a young and clueless new congressman, who must summon up his political courage to save her. Biel plays the waitress, Gyllenhaal the congressman. Keener will be playing a self-serving congresswoman, and Marsden the small-town boyfriend of Alice. Hopefully he's not the one who shot her with a nail. Morgan's character has yet to be decided.
Like I said, there is probably something I am not seeing. The script is penned by Russell and Kristen Gore, so the charm must lie there. But is the waitress' naivete the reason she was shot in the head? Or is she naive because she thinks her insurance will cover the cost of her injury? And must James Marsden lose a girl not only to Wolverine, to Superman and to Patrick Dempsey, but to Congressman Jake Gyllenhaal too?
To be fair, I'm willing to give Mr. Russell a fair shot after the surprisingly unique Three Kings -- although people still keep dissuading me from seeing I Heart Huckabees.